迪士尼彩乐园有反水么 BIOCELL期刊 Vol.48, No.12, 2024 上线

BIOCELL 2024年48卷第12期著作已上线。本期裁剪精选了三篇综述著作，重心温雅了靶向胆管癌微环境、2型糖尿病与帕金森疾病病理的互相作用、以及癌细胞周期的调养后劲等规模的关连前沿测度进展。以下是本期精选著作的珍爱概览，但愿通过与读者共享关连规模内的最新动态，为您提供测度想路和利用参考。接待您的阅读和反映。

1. Emerging pharmaceutical therapies for targeting cholangiocarcinoma microenvironment and chemokine pathways

靶向胆管癌微环境与趋化因子通路的新兴药物疗法

ARMAND N. YAZDANI, MICHAELA PLETSCH, ABRAHAM CHORBAJIAN, DAVID ZITSER, VIKRANT RAI*

Figure 2: General principle of innate immune response. This figure displays different cells of the innate immune system, such as macrophages, neutrophils, and dendritic cells, and the process by which the innate immune system acts to recognize pathogens to create a host immune response. This process involves a sensor that leads to cell production of pro-inflammatory cytokines and the migration of effector cells (neutrophils, macrophages, T cells, and B cells) to inflammation. While this often occurs in infection, it can also occur within tumor microenvironments in response to pro-inflammatory signaling. The figure is created using BioRender.

夹杂型胆管癌是一种零星且侵袭性极强的胆谈上皮细胞肿瘤增殖面孔，占原发性肝癌的比例高达20%。它是第二大常见的原发性肝恶性肿瘤，其确诊时的5年糊口率不到10%，且与多种炎性疾病密切关连。连年来，对肿瘤微环境的新发现和新意会为胆管癌的靶向调养提供了新的契机。具体而言，包括细胞疫苗、肿瘤关连中性粒细胞以及肝星状细胞在内的新式药物可能成为清雅的调养靶点。本综述旨在探究靶向胆管癌微环境极端致病机制中趋化因子通路的新兴药物疗法，并对建议的药物调养有谋略进行风险-收益分析。 异日的测度应力争于于优化和耕作 MUC1 和 WT1 等肿瘤卵白疫苗的疗效，尤其是探索将这些疫苗与免疫检讨点阻碍剂等其他免疫调养计谋相接使用的后劲。

援用法子：

APA Style

YAZDANI, A.N., PLETSCH, M., CHORBAJIAN, A., ZITSER, D., RAI, V. (2024). Emerging pharmaceutical therapies for targeting cholangiocarcinoma microenvironment and chemokine pathways. BIOCELL, 48(12), 1683–1702.https://doi.org/10.32604/biocell.2024.056252

Vancouver Style

YAZDANI AN, PLETSCH M, CHORBAJIAN A, ZITSER D, RAI V. Emerging pharmaceutical therapies for targeting cholangiocarcinoma microenvironment and chemokine pathways. BIOCELL. 2024;48(12):1683–1702.https://doi.org/10.32604/biocell.2024.056252

IEEE Style

A. N. YAZDANI, M. PLETSCH, A. CHORBAJIAN, D. ZITSER, and V. RAI, “Emerging pharmaceutical therapies for targeting cholangiocarcinoma microenvironment and chemokine pathways,” BIOCELL, vol. 48, no. 12, pp. 1683–1702, 2024.https://doi.org/10.32604/biocell.2024.056252

2. Unraveling the molecular crossroads: T2DM and Parkinson’s disease interactions

解开分子交织点：2型糖尿病与帕金森病的互相作用

TINGTING LIU#, XIANGRUI KONG#, JIANSHE WEI*

Figure 6: T2DM is negatively related to PD. Nicotine leads to dysfunction of pancreatic β cells and exacerbates IR, while inhibiting inflammatory factors reduces PD symptoms. The Sirtuins family inhibits inflammation and fatty acid oxidation, reduces T2DM, activates inflammatory factors, causes oxidative stress, and exacerbates α-syn aggregation, leading to the occurrence of PD. Red represents inhibition, green represents activation.

2型糖尿病（T2DM）是一种以抓续性高血糖为特征的慢性代谢性疾病。连年来，T2DM患者中帕金森病（PD）发生风险加多的表象逐步泄露。然则，T2DM与PD病剪发生之间互相作用的分子机制尚未十足证据。本综述详尽了其中一些共同的病理生理机制，包括遗传风险身分、高血糖、胰岛素抵牾（IR）、炎症、线粒体功能退却、氧化应激、自噬以及晚期糖基化终居品（AGEs），迪士尼彩乐园这些机制零丁或协同地促成了T2DM和PD的发生和发展。此外，本文还汇总了探究T2DM与PD关系的关连测度，这些测度可能为T2DM和PD的替代调养计谋提供新的想路。

援用法子：

APA Style

LIU, T., KONG, X., WEI, J. (2024). Unraveling the molecular crossroads: T2DM and parkinson’s disease interactions. BIOCELL, 48(12), 1735–1749. https://doi.org/10.32604/biocell.2024.056272

Vancouver Style

LIU T, KONG X, WEI J. Unraveling the molecular crossroads: T2DM and parkinson’s disease interactions. BIOCELL. 2024;48(12):1735–1749. https://doi.org/10.32604/biocell.2024.056272

IEEE Style

T. LIU, X. KONG, and J. WEI, “Unraveling the molecular crossroads: T2DM and Parkinson’s disease interactions,” BIOCELL, vol. 48, no. 12, pp. 1735–1749, 2024. https://doi.org/10.32604/biocell.2024.056272

3. Targeting cell cycle regulators: A new paradigm in cancer therapeutics

靶向细胞周期调节因子：癌症调养的新范式

GARIMA SINGH#, SONIKA KUMARI SHARMA#, NEELU MISHRA, AASTHA SONI, MANSHI KUMARI, SAMARENDRA KUMAR SINGH*

Graphic Abstract

连年来，对癌细胞易理性的深切测度揭示了遴荐性靶向恶性细胞中细胞周期的调养后劲。本综述重心照拂了癌细胞中主要的细胞周期失调，并先容了现在在临床奉行中或临床侦查阶段的靶向细胞周期因子的抗癌药物的最新进展。鉴于癌症患者中抗药性的不停加多，著作还探究了针对这些细胞周期因子的潜在调养有谋略的机制视力。此外，著作详尽了开导新疗法和优化现存疗法以收尾最大疗效所需的异日测度观念。

援用法子：

APA Style

SINGH, G., SHARMA, S.K., MISHRA, N., SONI, A., KUMARI, M. et al. (2024). Targeting cell cycle regulators: A new paradigm in cancer therapeutics. BIOCELL, 48(12), 1639–1666. https://doi.org/10.32604/biocell.2024.056503

Vancouver Style

SINGH G, SHARMA SK, MISHRA N, SONI A, KUMARI M, SINGH SK. Targeting cell cycle regulators: A new paradigm in cancer therapeutics. BIOCELL. 2024;48(12):1639–1666. https://doi.org/10.32604/biocell.2024.056503

IEEE Style

G. SINGH, S. K. SHARMA, N. MISHRA, A. SONI, M. KUMARI, and S. K. SINGH, “Targeting cell cycle regulators: A new paradigm in cancer therapeutics,” BIOCELL, vol. 48, no. 12, pp. 1639–1666, 2024.https://doi.org/10.32604/biocell.2024.056503

BIOCELL期刊简介

主编

Alfredo Castro-Vazquez

Manuel A. Barbieri

BIOCELL 是一册开源月刊，旨在发表分子细胞生物学规模的高质地论文。

本刊温雅的主题包括但不限于：细胞生物学、结构与分子生物学、免疫学、病理学和神经生物学、基因组学、转录组学、卵白质组学和代谢组学、植物分子与细胞生物学、缠绵生物学等。

《海边的向日葵》是一篇关于救赎和悬疑推理的小说。讲述了男、女主人公在极端情形下做出了“恶”的决定后，面对各自背负的一条“人命”，精神上饱受煎熬，于是，原本生活中没有交集的两个人，展开了一场自我救赎、相互救赎、精神救赎的过程。男主人公偶然在海边作的一幅向日葵墙画，成了他们涅槃重生的开始。

BIOCELL官网：https://www.techscience.com/journal/biocell

BIOCELL官邮：[email protected]迪士尼彩乐园有反水么